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Promising investigational therapeutic monoclonal antibody to treat chronic hepatitis B and D infections

Promising investigational therapeutic monoclonal antibody to treat chronic hepatitis B and D infections
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New recommendations for optimization, validation of the quantitative measurement of HBV cccDNA

New Standards to Measure Hepatitis B in Liver Cells

New Standards to Measure Hepatitis B in Liver Cells
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New combination therapy proven to be highly effective in HBV infection model

New combination therapy proven to be highly effective in HBV infection model Around 260 million people, more than three percent of the global population, are chronically infected with the hepatitis B virus (HBV); in the long term, this often leads to complications such as liver cirrhosis and liver cancer. A cure is not yet possible with the available medication. Scientists at the German Center for Infection Research (DZIF) and the University Hospital Eppendorf (UKE) have now investigated a new combination therapy that has proven highly effective in their infection model. The new therapeutic approach is based on shutting down the viral hepatitis B genome located in the nucleus of infected liver cells. Upon infection of the liver cell, the viral genome is transformed inside the nucleus into a closed circular DNA molecule. This deoxyribonucleic acid is a stable molecule known as covalently closed circular DNA (cccDNA) and serves as the template for the production of new viruses.

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