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The results of a randomized clinical trial suggest a shorter course of antibiotics in children who have community-acquired pneumonia (CAP) is as effective as a longer course, Canadian researchers reported this week in
JAMA Pediatrics.
The noninferiority trial, involving children at two Canadian hospitals who had CAP that did not require hospitalization, found that clinical cure rates were similar in children treated with 5 days of amoxicillin versus those treated with 10 days.
The authors of the study say the findings are consistent with randomized clinical trials (RCTs) that have found short-course antibiotic therapy is preferable in adults with CAP, and suggest that clinical practice guidelines, in accordance with antimicrobial stewardship principles, should consider recommending 5 days of antibiotics for management of pediatric CAP.