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Newly Published Research by Mason School Faculty Explores Congress's Unintended Consequences of the CARES Act

Congress passed the Coronavirus Aid, Relief, and Economic Security (CARES) Act in late March 2020 in response to the economic fallout of the COVID-19 pandemic…

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Taconic Biosciences Launches New COVID-19 Mouse Model

Taconic Biosciences Launches New COVID-19 Mouse Model Expands COVID-19 Research Toolkit with novel hACE2 AC22 Mouse RENSSELAER, N.Y., April 29, 2021 (GLOBE NEWSWIRE) -- Taconic Biosciences, a global leader in providing drug discovery animal model solutions, announces the launch of a new COVID-19 mouse model. This human ACE2 (hACE2) transgenic mouse expands Taconic's COVID-19 research toolkit. In October 2020, Taconic launched its first hACE2 model. The AC70 mouse experiences a lethal response to infection by SARS-CoV-2, the virus that causes COVID-19. Conversely, the new AC22 mouseis lethality-resistant, enabling therapeutic, vaccine, and post-infection symptom research. Although various hACE2 mouse models of lethal SARS-CoV-2 infection exist, the hACE2 AC22 lethality-resistant model is important because it permits study of sublethal infection. Most humans infected with SARS-CoV-2 survive, and an animal model which replicates sublethal disease and recovery is needed. The hACE2 AC22 mouse provides a longer study window to assess drug efficacy compared to lethal infection models.

Taconic Biosciences Launches New COVID-19 Mouse Model - News Makers

Taconic Biosciences Launches New COVID-19 Mouse Model Expands COVID-19 Research Toolkit with novel hACE2 AC22 Mouse RENSSELAER, N.Y., April 29, 2021 (GLOBE NEWSWIRE) — Taconic Biosciences, a global leader in providing drug discovery animal model solutions, announces the launch of a new COVID-19 mouse model. This human ACE2 (hACE2) transgenic mouse expands Taconic’s COVID-19 research toolkit. In October 2020, Taconic launched its first hACE2 model. The AC70 mouse experiences a lethal response to infection by SARS-CoV-2, the virus that causes COVID-19. Conversely, the new AC22 mouse is lethality-resistant, enabling therapeutic, vaccine, and post-infection symptom research. Although various hACE2 mouse models of lethal SARS-CoV-2 infection exist, the hACE2 AC22 lethality-resistant model is important because it permits study of sublethal infection. Most humans infected with SARS-CoV-2 survive, and an animal model which replicates sublethal disease and recovery is needed. The hACE2 AC22 mouse provides a longer study window to assess drug efficacy compared to lethal infection models.

Taconic Biosciences Expands Immuno-oncology Animal Model Portfolio

Taconic Biosciences Expands Immuno-oncology Animal Model Portfolio Critical Jh Syngeneic Tumor Model Host Now Available on a B6 Background RENSSELAER, N.Y., Jan. 18, 2021 (GLOBE NEWSWIRE) -- Taconic Biosciences, a global leader in providing drug discovery animal model solutions, announces an expansion of its immuno-oncology portfolio. Immuno-oncology is a leading research priority because it uses the body's own immune system to effectively treat some types of cancer. Syngeneic tumor animal models play a critical role because they use standard inbred mice that have a competent immune system, which is required to evaluate immune-modulating therapies. These models are engrafted with mouse tumors derived from the same strain background; this genetic similarity between tumor and host prevents the host from rejecting the tumor.

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