Microenvironment Program News Today

Nuclear pore complexes (NPCs) are channels composed of multiple proteins that ferry molecules in and out of the nucleus, regulating many critical cellular

Immunotherapy is based on harnessing a person's own immune system to attack cancer cells.

Nuclear pore complexes (NPCs) are channels composed of multiple proteins that ferry molecules in and out of the nucleus, regulating many critical

Within the family of cell membrane lipids known as phosphoinositides and the kinase enzymes that regulate them, phosphoinositide 3-kinases (PI3Ks) have been cast in a starring role as scientists study their involvement in cancer, diabetes and many cellular activities.

Brooke Emerling, Ph.D., co-director of, and associate professor in, the Cancer Metabolism and Microenvironment Program at Sanford Burnham Prebys, is contri

Ze'ev Ronai, PhD, discusses key advancements in the treatment of patients with melanoma, including the discovery of NRAS and BRAF mutations, as well as the development of immunotherapy approaches.

Study of cell exhaustion in immunotherapy-resistant tumors could significantly improve the benefits of cancer immunotherapy for patients with treatment resistant types of cancer.

The new technique, which was just published in Cell Reports, can reduce T cell fatigue even in cancers that are resistant to clinically approved immunotherapies. It can also keep T cells from becoming exhausted.  

When the immune systems T cells are constantly stressed as a result of cancer or other chronic diseases, they suffer a process known as T cell fatigue

He immune system's T cells undergo a process known as T cell exhaustion when they are constantly stressed out as a result of cancer or other chronic disorders. Without functioning T cells, which destroy tumour cells, our bodies are unable to combat cancer. In order to increase the immune system's capacity to eliminate malignant cells, one of the main objectives of immunotherapy is to reverse T cell fatigue.