Four minutes later, the Gabon international grabbed his first career hat-trick and Akintola made it 4-0 in the 35th minute after benefitting from an assist from Senegal's Mame Diouf.
Towards the end of the first-half, Boupendza linked up with his Nigerian teammate and made it 5-0 for Hatayspor while Mirkan Aydin completed the emphatic win for the visitors on the stroke of full-time.
Tuesday's heroics took Boupendza's tally to seven goals after 12 league appearances which made the 24-year-old the second-highest African goalscorer in the Turkish Super Lig after Cameroon's Vincent Aboubakar, who has eight goals to his name at Besiktas.