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The estimands framework: a primer on the ICH E9(R1) addendum

Estimands can be used in studies of healthcare interventions to clarify the interpretation of treatment effects. The addendum to the ICH E9 harmonised guideline on statistical principles for clinical trials (ICH E9(R1)) describes a framework for using estimands as part of a study. This paper provides an overview of the estimands framework, as outlined in the addendum, with the aim of explaining why estimands are beneficial; clarifying the terminology being used; and providing practical guidance ...
United Kingdom T Ai Pei South Korea Republic Of Korea Suzie Cro Joanna Hindley
Source: bmj.com

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