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New research supports pridopidine's neuroprotective properties in Huntington's Disease models

 E-Mail Newly published papers further elucidate the mechanisms underlying pridopidines neuroprotective properties through activation of the Sigma-1 Receptor (S1R). Pridopidine enhances mitochondrial function and reduces mHTT-induced ER stress, which are impaired in HD, mediated by the S1R. Three new peer-reviewed publications highlight pridopidines therapeutic potential and provide data supporting the role of the S1R in neurodegenerative diseases Prilenia Therapeutics B...
Michaelr Hayden Huntington Study Group Healey Center International Journal Of Molecular Sciences Mediates Pridopidine Rescue Mitochondrial Function

FDCA ameliorates SU5416/hypoxia-induced PASMC dysfunction

Background: Pulmonary arterial hypertension (PAH) is an incurable disease that urgently needs therapeutic approaches. Based on the therapeutic effects of fasudil and dichloroacetate (DCA) on PAH, we aimed to explore the effects and potential mechanism of a new salt, fasudil dichloroacetate (FDCA), in a SU5416 plus hypoxia (SuHx)-induced rat model of PAH. Methods: The rat model of PAH was established by a single subcutaneous injection of SU5416 (20 mg/kg) followed by hypoxia (10% O 2) exposure f...
United States San Diego United Kingdom Pasmcs Sciencell Laboratory Animals Chemical Technology Co Ltd

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