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Experts debate obesity vs. glycemic control as primary target for treating type 2 diabetes

NEW ORLEANS — There is no single answer when it comes to determining the primary target for treating type 2 diabetes, two speakers said during a debate at the American Diabetes Association Scientific Sessions. Promoting weight loss to improve health outcomes for people with type 2 diabetes is one of the targets emphasized in the 2022 ADA Standard of Care. Ildiko Lingvay, MD, MPH, MSCS,
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Source: healio.com

Benefits of tubeless closed-loop insulin delivery system sustained at 1 year in young kids

NEW ORLEANS — New data show sustained glycemic improvements and safety at 1 year in very young children with type 1 diabetes who used a tubeless hybrid closed-loop insulin delivery system, researchers reported.Improved glycemic outcomes and safety in the initial 3-month pivotal study of the Omnipod 5 system (Insulet) in very young children persisted for an additional 9 months in an ongoing
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Source: healio.com

Food allergy associated with lower SARS-CoV-2 infection risk

People with food allergies showed lower risk for SARS-CoV-2 infection, whereas those with obesity had a higher risk, according to a study published in The Journal of Allergy and Clinical Immunology. Additionally, results of the perspective surveillance study showed asthma did not positively or negatively impact risk for SARS-CoV-2 infection.
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Source: healio.com

Infliximab may lead to higher infection rate, no improvement in transplant outcomes

The use of infliximab in patients with a deceased donor kidney transplant led to increased infections and did not improve allograft survival, according to data presented at the American Transplant Congress. “The intervention had no effect on allograft function or acute rejection,” Peter S. Heeger, MD, a professor of medicine and immunology at the Icahn School of Medicine at Mount
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Source: healio.com

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Dostarlimab shows efficacy as curative-intent treatment in rectal cancer subset

CHICAGO — Dostarlimab, an anti-PD-1 monoclonal antibody, demonstrated a 100% clinical complete response rate among a small cohort of patients with mismatch repair-deficient locally advanced rectal cancer, phase 2 study results showed.Longer follow-up is needed to examine the duration of treatment response in this patient population, according to researchers of the study, reported at ASCO
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Source: healio.com

CAR-T safe, effective for large B-cell lymphoma regardless of race or ethnicity

CHICAGO — Axicabtagene ciloleucel exhibited comparable efficacy and safety for large B-cell lymphoma regardless of patients’ race or ethnicity, according to study results presented at ASCO Annual Meeting.Data from a real-world analysis revealed some disparities in objective and complete response rates but no statistically significant differences in measures of treatment durability for
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Source: healio.com

Radiotherapy comparable to concurrent chemoradiotherapy in nasopharyngeal cancer subset

CHICAGO — Intensity-modulated radiotherapy conferred disease control and survival outcomes comparable to concurrent chemoradiotherapy but with less toxicity among patients with low-risk nasopharyngeal carcinoma, according to study results.The findings of the randomized phase 3 noninferiority trial, presented at ASCO Annual Meeting, suggested concurrent chemotherapy (CCRT) could be safely
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Source: healio.com

Q&A: Pegloticase sustained lower serum urate in kidney transplant recipients with gout

Among kidney transplant recipients with uncontrolled gout, pegloticase showed sustained decreased serum urate levels, according to findings presented at the American Transplant Congress.Patients also showed pain relief and decreased disability without worsening kidney function.
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Source: healio.com

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