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First-line therapy with axicabtagene ciloleucel induced objective responses in 89% of patients with high-risk large B-cell lymphoma, according to phase 2 study results.An estimated 91% of patients treated with a single infusion of the chimeric antigen receptor T-cell therapy remained alive at 12 months, a primary analysis of the ZUMA-12 trial showed.

Age variability in symptom onset of Alzheimer’s disease in those with Down syndrome was comparable to those who experienced autosomal dominant AD, while mortality was also similar, according to a study published in JAMA Network Open. “Down syndrome is a complex condition with multiple associated comorbidities that vary throughout the lifespan. Improvements in health care ... have

For some atopic dermatitis patients treated with tralokinumab who do not reach clear or almost clear skin, clinically meaningful results can still occur. “The FDA approves drugs in atopic dermatitis based solely on the proportion of patients or percentage of patients who get clear or almost clear after 16 weeks of treatment,” Eric Simpson, MD, director of the clinical studies unit at

Adults with diabetes and neuropathy experience significantly more fatigue than those with diabetes and no neuropathy and people without diabetes, according to a speaker at the American Association of Clinical Endocrinology annual meeting.

Interdisciplinary care was associated with higher odds of being listed for kidney transplant among patients with incident end-stage kidney disease in underrepresented groups, according to this study.Further, researchers found interdisciplinary care provides better ESKD preparedness than the usual nephrology care in this population.

Adults and children have different experiences with food protein-induced enterocolitis syndrome, although more research is necessary, according to a study published in The Journal of Allergy and Clinical Immunology: In Practice. Specifically, unlike what has been document in the pediatric population, the adult cohort less frequently experienced vomiting, severe acute episodes and development of

FORT LAUDERDALE, Fla. — A machine-learning algorithm showed the ability to identify spectral-domain OCT predictors of geographic atrophy in eyes with intermediate age-related macular degeneration.

SAN DIEGO — Enterosgel, a CE-certified intestinal absorbent, reduced short-term symptoms of stool consistency and abdominal pain among patients with irritable bowel syndrome with diarrhea, according to research. “The RELIEVE-IBS-D study was set up to investigate the efficacy and safety of Enterosgel for the treatment of irritable bowel syndrome with diarrhea. Enterosgel is a

SAN DIEGO — Patients who underwent laparoscopic anti-reflux surgery for gastroesophageal reflux disease experienced long-term improvement in symptoms commonly misperceived to persist, according to study results. “Our take home-message is to make patients as well as our colleagues — not only the surgeons but also the primary care physicians and gastroenterologists — who

AVT04, a biosimilar candidate to ustekinumab developed by Alvotech, met the primary endpoint in a confirmatory clinical study of patients with chronic plaque-type psoriasis, according to a company press.