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FDA approves tirzepatide, first dual incretin agonist for type 2 diabetes

The FDA announced it approved the injectable dual incretin agonist tirzepatide to improve glucose response in adults with type 2 diabetes in addition to diet and exercise.Tirzepatide (Mounjaro, Eli Lilly) is a first-in-class medicine that activates both the GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors, which leads to improved glucose control. Tirzepatide is injected once
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Source: healio.com

Sex steroid levels, bone markers align with skeletal development in boys during puberty

Serum levels of sex steroids and bone metabolism markers align with skeletal development in boys during puberty, though development can vary based on pubertal stage, according to study findings published in Bone. “Serum levels of sex steroids, insulin-like growth factor I and bone metabolism markers reflect skeletal development during puberty,” Bruno Lapauw, MD, PhD, professor in the
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Source: healio.com

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CDC reports more than 107,000 overdose deaths in 2021

The CDC estimates that 107,622 overdose deaths occurred in 2021, a 14.9% increase from 2020, which previously held the record for overdose deaths in a 12-month period, according to a report from the National Center for Health Statistics. Rahul Gupta, MD, MPH, MBA, FACP, White House Office of National Drug Control Policy director, said in the report that a life is lost to overdose every 5
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Source: healio.com

No increased CV, death risk with ticagrelor plus proton pump inhibitor therapy after PCI

Concomitant proton pump inhibitor plus ticagrelor monotherapy after PCI does not increase risk for all-cause death or an adverse CV event, in contrast with conventional post-PCI antiplatelet therapy, researchers reported.In a post hoc analysis of the GLOBAL LEADERS trial, researchers found that patients taking a proton pump inhibitor (PPI) treated with the conventional post-PCI treatment strategy
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Source: healio.com

'Communication is key' to reduce suicide risk after cancer diagnosis

Hemonc Today | Studies consistently have shown patients with cancer have a higher risk for suicide than the general public.A population-based study of more than 4.6 million patients with cancer showed an excess risk for suicide within 1 year after diagnosis of 2.51 per 10,000 person-years. In that study, published in 2019 in Cancer, Saad and colleagues observed the highest increases in suicide rates following
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Source: healio.com

LOGICS: Levoketoconazole improves cortisol control in endogenous Cushing's syndrome

SAN DIEGO — Compared with placebo, levoketoconazole improved cortisol control and serum cholesterol levels for adults with endogenous Cushing’s syndrome, according to results from the LOGICS study presented here. Safety and efficacy of levoketoconazole (Recorlev, Xeris Biopharma) for treatment of Cushing’s syndrome were established in the pivotal phase 3, open-label SONICS
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Source: healio.com

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