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WASHINGTON — Tranexamic acid administered intravenously before and after noncardiac surgery lowered the risk for life-threatening, major and critical organ bleeding compared with placebo, according to results of the POISE-3 trial.Although 1 g IV bolus tranexamic acid cut bleeding risk at 30 days, noninferiority was not established for the composite vascular outcome compared with placebo,

A week of physical inactivity has the same negative mental impact as a week of broken sleep, a study by sports equipment company Asics revealed. These results come from the company’s Mind Race study, in which participants who exercise regularly paused their workouts for a week and reported a 23% increase in racing thoughts after 7 days of physical inactivity.

The 2022 American College of Cardiology Scientific Session will be held live in Washington, D.C., from April 2 to 4, and virtually, with 39 late-breaking trials and featured clinical research presentations.“I am most excited about the fact that we are back to live education ... in the city that is the home of the ACC Heart House. So, welcome back and welcome home,” Pamela B. Morris,

A large study conducted in five African countries identified an easier and less toxic treatment for HIV-associated cryptococcal meningitis that includes a single high dose of liposomal amphotericin B.

Higher fiber intake, specifically cereal fiber, was associated with lower levels of inflammation and a reduced risk for CVD in older adults, according to findings published in JAMA Network Open.“This is interesting as it suggests that cereal fiber, more so than vegetable or fruit fiber, may be most useful to reduce inflammation and/or CVD risk; this will, however, need to be confirmed in

Convalescent plasma, when administered within 9 days of symptom onset in patients with COVID-19, may reduce the risk for hospitalization, according to data published in The New England Journal of Medicine. “While everyone was focused on treating people in the hospital after progression of disease, we saw the need to keep people out of the hospital rather than wait until they were near

Large amounts of tau proteins in the brain affected memory function only when amyloid protein burden was also high in those with Alzheimer’s disease, data suggests in a study published in Brain. “It has long been known that deposits of tau proteins in the so-called hippocampus and in neighboring brain areas impair memory,” Emrah Düzel, MD, director of the Institute of

More than one-third of high school students in the United States reported experiencing poor mental health during the COVID-19 pandemic, according to survey results published in MMWR.

The amygdala, which is enlarged in children aged 2 years who are diagnosed with autism spectrum disorder, appears to accelerate in growth in the first 6 to 12 months of life, researchers reported in The American Journal of Psychiatry. “This suggests that early, presymptomatic brain changes in infancy may represent a cascade of linked brain and behavior changes that lead to the emergence of

Ivermectin did not lower the incidence of hospitalization among high-risk adults with COVID-19 enrolled in a large double-blind, randomized, placebo-controlled trial in Brazil, researchers reported in The New England Journal of Medicine.