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In mice, antibody removes amyloid, improves vessel function without raising risk of brain bleeds Amyloid deposits (blue) in mouse brain tissue and blood vessels are reduced after treatment with an antibody that targets the protein APOE (right), a minor component of amyloid deposits, compared to a placebo antibody (left). Amyloid deposits in the brain increase the risk of dementia and strokes. Researchers at Washington University School of Medicine in St. Louis have identified an antibody that clears amyloid deposits from the brain without raising the risk of brain bleeds. (Image: Monica Xiong) February 17, 2021 SHARE As people age, a normal brain protein known as amyloid beta often starts to collect into harmful amyloid plaques in the brain. Such plaques can be the first step on the path to Alzheimer’s dementia. When they form around blood vessels in the brain, a condition known as cerebral amyloid angiopathy, the plaques also raise the risk of strokes.

David holtzmanRalphg daceyGretchenp jonesGregoryj zipfelMonica xiongDepartment of neurosurgeryDepartment of neurologyWashington university school of medicineWashington university schoolScience translational medicineDistinguished professorNeurological surgeryடேவிட் ஹோல்ட்ஸ்மேன்மோனிகா க்ஷ்ிொன்துறை ஆஃப் நரம்பியல் அறுவை சிகிச்சைதுறை ஆஃப் நரம்பியல்