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Coronary artery calcium score, not polygenic risk score, best predicts heart disease risk

Data show CV risk discrimination improved when adding a coronary artery calcium score to a CHD prediction model based on traditional risk factors; however, there were no changes when adding a polygenic risk score.The analysis of two large cohorts of middle-age and older adults with long-term follow-up — all with available genetic data and coronary CT scans — addresses a key knowledge
United States Sadiya Sana Khan American Heart Association Northwestern University Feinberg School Of Medicine Northwestern University Feinberg School Multi Ethnic Study
Source: healio.com

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CT scan best at predicting heart disease risk

CT scans are better at predicting a middle-aged person’s risk for a heart disease, such as a heart attack, than genetics, reports a new Northwestern Medicine study. Conventional measures of risk factor levels include blood pressure and cholesterol. Scientists had hoped genetics could better predict risk than conventional measure, but only when considering CT scan, half the study participants moved into the high-risk group.
United States Zuid Holland Donaldm Lloyd Jones Sadiya Khan Norrina Allen Northwestern University Feinberg School Of Medicine

OSA traits, severity differ according to common demographic factors

The prevalence of three pathophysiological traits used to identify patients with sleep apnea differs according to BMI, sex, age and race/ethnicity, according to study results published in Annals of the American Thoracic Society.“The present community-based study shows that endotypic traits for sleep apnea vary with age, sex, race/ethnicity, and obesity and provides the largest collection of
United States Scotta Sands Annals Of The American Thoracic Society Harvard Medicine School American Thoracic Multi Ethnic Study
Source: healio.com

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