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Heparin s COVID-19 Benefit Greatest in Moderately Ill Patients

Therapeutic levels of heparin can have widely varying effects on COVID-19 patients depending on the severity of their disease, according to a multiplatform clinical trial.

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Early treatment with anticoagulant may reduce risk of death moderately ill hospitalized COVID-19 patients: Study

Early treatment with anticoagulant may reduce risk of death moderately ill hospitalized COVID-19 patients: Study
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Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis | Critical Care Medicine | JAMA

Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis | Critical Care Medicine | JAMA
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Tocilizumab and sarilumab shown to be effective in critical COVID-19

A new study, released as a preprint on the medRxiv server, describes how a team of researchers from the University Medical Center Utrecht in the Netherlands explored the efficacy of four monoclonal antibodies that antagonize powerful pro-inflammatory pathways. The team sought to determine which were useful in treating critically ill COVID-19 patients on organ support.

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Analysis spotlights shortage of a COVID-19 drug in Canada

Tocilizumab, like other potential COVID-19 drug treatments, is in spot shortages around the world. In India, it s being allocated to states by the government. The UK National Health Service allows patients to receive only one dose. And in Canada, whose use of the drug was the spotlight of a CMAJ analysis yesterday, it s considered to be in tier 3 shortage, a status reserved for potential COVID-19 drugs that allows them to be withheld owing to scarcity. Canada s shortage could cause supply and demand issues, according to the researchers. They estimate that, if the drug is proven to reduce in-hospital mortality, 42.9% of hospitalized COVID patients in Canada and 40.9% of hospitalized COVID patients in the United States could benefit from treatment.

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