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Author summary Why was this study done? Emulsifiers are widely used food additives in industrially processed foods to improve texture and enhance shelf-life. Experimental in vivo/in vitro research as well as a pilot clinical trial on healthy individuals suggests deleterious effects of food additive emulsifier intake on the intestinal microbiota, metabolome, host inflammation, and susceptibility to carcinogenesis. To our knowledge, due to challenges to accurately estimate the exposure to food additive emulsifiers through diet, so far there was no available epidemiological evidence from prospective cohorts on food additive emulsifier intakes in relation to cancer risk. What did the researchers do and find? This study assessed quantitative exposures to a wide range of food additive emulsifiers in a large prospective cohort of adults. Higher intakes of mono- and diglycerides of fatty acids (FAs) (E471), total carrageenans (E407, E407a), and carrageenan (E407) were associated with higher risks of overall, breast, and/or prostate cancers. What do these findings mean? These results provide important epidemiological insights into the role of emulsifiers on cancer risks, and need to be confirmed in further epidemiological and experimental research.
ParisFrance-generalFranceCambridgeCambridgeshireUnited-kingdomNorwayUnited-statesAmericanFrenchNorwegianPorcher-universitAlthough many Medicare beneficiaries with heart failure (HF) are discharged with home health services, little is known about mortality and hospice use in this group.To identify risk factors of 6-month mortality and hospice use among hospitalized HF patients who receive home health, which could inform efforts to improve palliative and hospice use for these patients.A
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