Page 17 - Nature Methods News Today

 E-Mail A new software tool allows researchers to quickly query datasets generated from single-cell sequencing. Users can identify which cell types any combination of genes are active in. Published in Nature Methods on 1st March, the open-access scfind software enables swift analysis of multiple datasets containing millions of cells by a wide range of users, on a standard computer. Processing times for such datasets are just a few seconds, saving time and computing costs. The tool, developed...

Nanotechnology Now Home > Press > How photoblueing disturbs microscopy Confocal fluorescence images of glass surfaces coated with the cyanine dyes Alexa Fluor 647 (a) and CF660C (b) and with carborhodamine dye ATTO647N (c) after light excitation at 568 nanometres (nm). By exciting the red-absorbing dyes at 640 nm in certain areas (negative images top right), dyes are photoconverted there and it is possible to write letters on the surface that were excited at 568 nm and fluoresce at about 580 nm...

 E-Mail IMAGE: Confocal fluorescence images of glass surfaces coated with the cyanine dyes Alexa Fluor 647 (a) and CF660C (b) and with carborhodamine dye ATTO647N (c) after light excitation at 568 nanometres... view more  Credit: Team Markus Sauer / University of Wuerzburg The latest developments in fluorescence microscopy make it possible to image individual molecules in cells or molecular complexes with a spatial resolution of up to 20 nanometres. However, under certain circumstance...

 E-Mail IMAGE: This is Dr. Danny Incarnato, a molecular geneticist at the University of Groningen, the Netherlands. In collaboration with colleagues from the University of Torino (Italy), his team developed a method... view more  Credit: University of Groningen Scientists at the University of Groningen (The Netherlands), in collaboration with colleagues from the University of Torino (Italy), have developed a method to visualize and quantify alternative structures of RNA molecules. The...

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Scientists develop a new method to study the molecular characteristics of T cells UT Southwestern scientists have developed a new method to study the molecular characteristics of T cells, critical immune cells that recognize and attack invaders in the body such as viruses, bacteria, and cancer. The approach, described today in the journal Nature Methods, enables researchers to more easily analyze the roles of T cell receptors (TCRs) - the molecules on the surfaces of T cells that are responsib...

 E-Mail IMAGE: The above illustration, in the center, shows activation of T cell immune response with the interaction of MHC-II (red) with the T cell receptor (TCR, blue), and also CD4 (light... view more  Credit: Art purchased from Alamy and modified by Dr. Tao Wang. DALLAS - Jan. 6, 2020 - UT Southwestern scientists have developed a new method to study the molecular characteristics of T cells, critical immune cells that recognize and attack invaders in the body such as viruses, bact...

Transcription Activator-Like Effector Nucleases Plants are constantly exposed to various biotic and abiotic stresses. Thus, scientists continue to develop tools that help improve the field of plant breeding. These new tools and practices are referred to as plant breeding innovations, which include both precision IT-based tools and new molecular breeding techniques. Precision breeding tools merge innovative digital devices— like sensors, detectors, and robotics—with management technolog...

Columbia researchers have created a new technology using synthetic llama antibodies to prevent specific proteins from being destroyed inside cells. The approach could be used to treat dozens of diseases, including cystic fibrosis, that arise from the destruction of imperfect but still perfectly functional proteins. In many genetic diseases, including cystic fibrosis, mutated proteins are capable of performing their jobs but are tagged for destruction by the cell’s quality control mechanisms....