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After Elon Musk, Mark Zuckerberg's Meta Joins Neural Tech Race; Developing Device To Read Brain Signals

Developing novel conducting polymer-hydrogel interpenetrating networks for neural interfacing

Researchers reveal how use of spinal cord stimulation for chemotherapy-related pain, cancer treatment

Washington, April 30: A recent study suggested that spinal cord stimulation (SCS) may be effective in lowering chronic pain in persons receiving active therapy with a standard anti-cancer medicine, according to researchers at Johns Hopkins University School of Medicine.

Researchers reveal how use of spinal cord stimulation for chemotherapy-related pain, cancer treatment

A recent study suggested that spinal cord stimulation (SCS) may be effective in lowering chronic pain in persons receiving active therapy with a standard anti-cancer medicine, according to researchers at Johns Hopkins University School of Medicine.

Spinal cord stimulation may help reduce chronic pain in people undergoing active cancer treatment

Researchers at Johns Hopkins University School of Medicine say they have evidence from a new study in rats that spinal cord stimulation (SCS) may be useful in reducing chronic pain in people undergoing active treatment with a common anti-cancer drug.

Research Advances Spinal Cord Stimulation for Cancer Pain & Treatment

Research Advances Spinal Cord Stimulation for Cancer Pain

Frontiers | Excitatory Repetitive Transcranial Magnetic Stimulation Over Prefrontal Cortex in a Guinea Pig Model Ameliorates Tinnitus

2School of Biological Sciences, University of Western Australia, Crawley, WA, Australia 3Perron Institute for Neurological and Translational Research, Crawley, WA, Australia Tinnitus, a phantom auditory perception that can seriously affect quality of life, is generally triggered by cochlear trauma and associated with aberrant activity throughout the auditory pathways, often referred to as hyperactivity. Studies suggest that non-auditory structures, such as prefrontal cortex (PFC), may be involved in tinnitus generation, by affecting sensory gating in auditory thalamus, allowing hyperactivity to reach the cortex and lead to perception. Indeed, human studies have shown that repetitive transcranial magnetic stimulation (rTMS) of PFC can alleviate tinnitus. The current study investigated whether this therapeutic effect is achieved through inhibition of thalamic hyperactivity, comparing effects of two common clinical rTMS protocols with sham treatment, in a guinea pig tinnitus model. Animals underwent acoustic trauma and once tinnitus developed were treated with either intermittent theta burst stimulation (iTBS), 20 Hz rTMS, or sham rTMS (10 days, 10 min/day; weekdays only). Tinnitus was reassessed and extracellular recordings of spontaneous tonic and burst firing rates in auditory thalamus made. To verify effects in PFC, densities of neurons positive for calcium-binding proteins, calbindin and parvalbumin, were investigated using immunohistochemistry. Both rTMS protocols significantly reduced tinnitus compared to sham. However, spontaneous tonic firing decreased following 20 Hz stimulation and increased following iTBS in auditory thalamus. Burst rate was significantly different between 20 Hz and iTBS stimulation, and burst duration was increased only after 20 Hz treatment. Density of calbindin, but not parvalbumin positive neurons, was significantly increased in the most dorsal region of PFC indicating that rTMS directly affected PFC. Our results support the involvement of PFC in tinnitus modulation, and the therapeutic benefit of rTMS on PFC in treating tinnitus, but indicate this is not achieved solely by suppression of thalamic hyperactivity.

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