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Interim Effectiveness of Updated 2023–2024 (Monovalent XBB 1 5) COVID-19 Vaccines Against COVID-19–Associated Hospitalization Among Adults Aged ≥18 Years with Immunocompromising Conditions — VISION Network, September 2023–February 2024

Shingles Vaccine Highly Effective Over 4 Years

Two-dose Shingrix vaccine also provided long-term protection in people taking corticosteroids

Effectiveness of Live Zoster Vaccine Wanes Over Time

Live zoster vaccination is initially effective against outcomes, including herpes zoster and admission for herpes zoster, but wanes overtime.

Effectiveness of Live Zoster Vaccine Wanes Over Time

Vaccine effectiveness highest in first year after vaccination and decreases considerably over time.

Effectiveness of the live zoster vaccine during the 10 years following vaccination: real world cohort study using electronic health records

Objectives To assess the effectiveness of live zoster vaccine during more than 10 years after vaccination; and to describe methods for ascertaining vaccine effectiveness in the context of waning. Design Real world cohort study using electronic health records. Setting Kaiser Permanente Northern California, an integrated healthcare delivery system in the US, 1 January 2007 to 31 December 2018. Population More than 1.5 million people aged 50 years and older followed for almost 9.4 million person years. Main outcome measure Vaccine effectiveness in preventing herpes zoster, postherpetic neuralgia, herpes zoster ophthalmicus, and admission to hospital for herpes zoster was assessed. Change in vaccine effectiveness by time since vaccination was examined using Cox regression with a calendar timeline. Time varying indicators were specified for each interval of time since vaccination (30 days to less than one year, one to less than two years, etc) and adjusted for covariates. Results Of 1â

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