The National Institutes of Health awarded the College of Dentistry’s Pain Research Center with an $8 million grant to support research toward treatments for oral cancer as an alternative to opioids. The funding is a part of Helping to End Addiction Long-term, an NIH initiative aiming to prevent and treat the overuse of opioids in.
Researchers have discovered that an altered version of an anti-nausea drug reaches inside cells to disrupt signaling and provide sustained pain relief.
Altering the chemical properties of an anti-nausea drug enables it to enter an interior compartment of the cell and provide long-lasting pain relief, according to a new study led by researchers at NYU College of Dentistry's Pain Research Center.
Results provide insights into strategies for antagonizing GPCRs in intracellular locations, with implications for designing improved treatments for disease.