Page 2 - Nuclear Envelope News Today

An HIV-1 capsid acts like a Trojan horse to deliver viral cargo in nuclear pore analogs, MIT researchers have discovered.

Researchers investigated the Role of Cylicins in Spermiogenesis and Male Fertility in Mice and Humans through Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/ CRISPR-associated protein 9 (Cas9) Gene Editing.

In this interview, News-Medical spoke to Dr. Jeremy Carlton and Professor Victoria Sanz-Moreno about their latest research into the spread of skin cancer.

Researchers discovered that the elevated expression of LAP1, an inner nuclear membrane protein, helps metastatic melanoma cells surmount the physical challenges presented by tissue structure and the microenvironment during metastasis.

Research led by Queen Mary University of London, King's College London and the Francis Crick Institute has identified a protein that makes melanoma, the most serious type of skin cancer, more aggressive by giving cancer cells the ability to change the shape of their nucleus – a characteristic which allows the cells to migrate and spread around the body.

A Northwestern Medicine study has uncovered distinct roles for major nuclear lamin isoforms in maintaining intracellular interactions and cellular mechanics, according to findings published in the Proceedings of the National Academy of Sciences.

Novocure announced that a new study published in the Journal of Clinical Investigation (JCI) finds treatment with Tumor Treating Fields (TTFields) mediated cell disruption activates the immune system and triggers an anti-tumor cell response that may be effectively used together with existing immunotherapy approaches in the treatment of solid tumors, with limited systemic toxicity.

Broccoli may contain advantages beyond nutrition. A molecule found in broccoli, cabbage and more digests down into DIM, a compound with brighter benefits than the name implies, such as inducing cell death in breast, prostate and colon cancer.

Context matters. It's true for many facets of life, including the tiny molecular machines that perform vital functions inside our cells.