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Reactive compounds cause cellular damage that is suspected to contribute to aging and neurodegenerative diseases. Oxidative stress and environmental factors likely contribute to this. Here we report that an enzyme mutated in Parkinson’s disease can prevent damage of metabolites and proteins caused by a metabolite from the central pathway of sugar metabolism. Inactivation of this enzyme in model systems, ranging from flies to human cells, leads to the accumulation of a wide range of damaged metabolites and proteins. Thus, this enzyme represents a highly conserved strategy to prevent damage in cells that metabolize sugars. Overall, we discovered a fundamental link between carbohydrate metabolism and a type of cellular damage that might contribute to the development of Parkinson’s disease. Mass spectrometry proteomics data have been deposited at ProteomeXchange, [www.proteomexchange.org/][1] (accession no. PXD029410) via the PRIDE partner repository ([62][2]). Processed mass spectrom

United kingdomFondation contre leDeutsche forschungsgemeinschaftEuropean union horizonDidier trono university of genevaEric fearon university of michiganUniversity animal welfare committeeEuropean research councilJp bolanos university of salamancaFeng zhang massachusetts institute of technologyUniversal problemLong standing enigmaProteins providesPleiotropic effectsPhosphatases that convertn phosphoglyceroylN glyceroyl adducts remain