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Extracellular Viscosity Linked to Cancer Spread

Cancer cells exposed to high viscosity move better and their metastatic potential increases

Higher viscosity of extracellular fluid enhances cancer dissemination

New research findings show how higher viscosity, or resistance to flow, of the extracellular fluid that surrounds cells enables cancer cells to migrate more rapidly from a primary tumor to other sites in the body.

Research projects at Auburn get funding boost from Breast Cancer Research Foundation of Alabama

Research projects across Alabama, including three at Auburn University, will benefit from more than $1.2 million in funding from the Breast Cancer Research Foundation of Alabama.

Breast Cancer Research Foundation of Alabama exceeds $1.2 million investment in Alabama-based research

Protein appears to prevent tumor cells from spreading via blood vessels

Loading video... VIDEO: In static conditions, cells enter microchannels, whereas 40-60% reverse direction when fluid is flowing. Courtesy of Johns Hopkins University. view more  Credit: Johns Hopkins University Researchers have identified a specialized protein that appears to help prevent tumor cells from entering the bloodstream and spreading to other parts of the body. "We have discovered that this protein, TRPM7, senses the pressure of fluid flowing in the circulation and stops the cells from spreading through the vascular system," said Kaustav Bera, a Johns Hopkins University PhD candidate in chemical and biomolecular engineering and a lead author of the study, which was done with colleagues at the University of Alberta and Universitat Pompeu Fabra.

Gut microbe may promote breast cancers

 E-Mail A microbe found in the colon and commonly associated with the development of colitis and colon cancer also may play a role in the development of some breast cancers, according to new research from investigators with the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy. Breast tissue cells exposed to this toxin retain a long-term memory, increasing the risk for disease. In a series of laboratory experiments, researchers discovered that when enterotoxigenic Bacteroides fragilis (ETBF) was introduced to the guts or breast ducts of mice, it always induced growth and metastatic progression of tumor cells. A description of the work is published in the January 6 issue of the journal