Page 2 - Pascal Sanchez News Today

When it comes to fashion, we are all inspired by what we see; whether it be a well-dressed celebrity, a blow-your-mind catwalk presentation or even a super stylish every-day passerby. As fashion editors, were moved by all of the above, and then some. Were exposed to under-the-radar labels; we get a first-hand look at collections months before they hit stores; were tapped into brands with chic-yet-cheap offerings and we shop — a lot. To share our knowledge, FEMAIL brings you Style Swoon, a wee...

06 Feb 2021 A new APP knock-in mouse has hit the scene. Researchers led by Pascal Sanchez, Denali Therapeutics, San Francisco, California, described the details in a paper posted to bioRxiv on January 20. They humanized the Aβ sequence in the mouse APP gene and knocked in three familial Alzheimer’s disease mutations: Swedish, Arctic, and Austrian. TREM2 expression and cytokine concentrations spiked in brain tissue, microglia flocked to plaques, neurites swelled, and tau and neurofilament lig...