Page 3 - Patrick Cramer News Today

Patrick Cramer appointed new President-elect of the Max Planck Society as of June 2023 -

The Göttingen-based Max Planck Institutes (MPI) for Biophysical Chemistry and Experimental Medicine have merged as of January 1, 2022. This will establish a new MPI, the Max Planck Institute for M ...

This year’s Gregori Aminoff Prize in crystallography has been awarded to researchers Elena Conti and Patrick Cramer in Germany and Seth Darst in the US, for their investigations of cellular systems supporting RNA development, a macromolecule which reads and interprets the information in the genome of all living organisms. Click to read more...

 E-Mail Under stress conditions, cells switch quickly from the normal to the crisis mode to prevent themselves from being damaged. This so-called heat shock response is associated with a rapid downregulation of gene activity to release capacities to cope with the threat. Researchers at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg have now discovered how exactly a stress-induced molecular droplet formation of the transcription regulator NELF downregulates transcription ...

Why are antibodies such an interesting research subject for epidemiologists during this pandemic? How do bamlanivimab and REGN-CoV-2 work? Both antibody treatments are designed to block the SARS-CoV-2 spike protein and thus prevent the virus from attaching to and entering human cells. These identical so-called monoclonal antibodies are lab-engineered and designed to attack one specific virus in one distinct way. Bamlanivimab contains one monoclonal antibody. REGN-CoV-2, in contrast, consists of...

Credit: Irene Böttcher-Gajewski / Max Planck Institute for Biophysical Chemistry The award is one of the most prestigious in Europe and endowed with 500,000 Swiss francs. With this prize the Louis-Jeantet Foundation honors the director at the Max Planck Institute (MPI) for Biophysical Chemistry for his pioneering work in the field of gene transcription. Transcription is a copying process enabling living cells to produce transcripts of their genes that then serve as blueprints for making protei...

Date Time Coronavirus: Weak Point of Remdesivir The drug Remdesivir only weakly inhibits the new coronavirus SARS-CoV-2. Research groups from Göttingen and Würzburg have discovered why this is so. The Covid-19 drug Remdesivir (purple) is incorporated into the new RNA chain during the copying process and suppresses the duplication of the coronavirus genome. (Image: Hauke Hillen, Goran Kokic, Patrick Cramer / Max-Planck-Institut für biophysikalische Chemie Göttingen) Remdesivir is the first ...

Credit: Hauke S. Hillen A newly developed compound starves cancer cells by attacking their "power plants" - the so-called mitochondria. The new compound prevents the genetic information within mitochondria from being read. Researchers from the Max Planck Institute for Biology of Ageing in Cologne, the Karolinska Institute in Stockholm and the University of Gothenburg report in their study that this compound could be used as a potential anti-tumour drug in the future; not only in mice but also i...

Researchers at Karolinska Institutet in Sweden report in the journal Nature that they have developed novel first-in-class inhibitors that compromise mitochondrial function in cancer cells. Treatment with the inhibitors stopped cancer cells from proliferating and reduced tumour growth in mice, without significantly affecting healthy cells. "We are excited to have shown that this novel principle for cancer treatment works in animal models and hopefully the inhibitors can now be developed further...