AIRE is an unconventional transcription factor that enhances the expression of thousands of genes in medullary thymic epithelial cells and promotes clonal deletion or phenotypic diversion of self-reactive T cells1–4. The biological logic of AIRE’s target specificity remains largely unclear as, in contrast to many transcription factors, it does not bind to a particular DNA sequence motif. Here we implemented two orthogonal approaches to investigate AIRE’s cis-regulatory mechanisms: construction of a convolutional neural network and leveraging natural genetic variation through analysis of F1 hybrid mice5. Both approaches nominated Z-DNA and NFE2–MAF as putative positive influences on AIRE’s target choices. Genome-wide mapping studies revealed that Z-DNA-forming and NFE2L2-binding motifs were positively associated with the inherent ability of a gene’s promoter to generate DNA double-stranded breaks, and promoters showing strong double-stranded break gen
United States Image Recognition Market To Expand At A CAGR Of 8 13% Over 2024-32 menafn.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from menafn.com Daily Mail and Mail on Sunday newspapers.
It’s been a busy year for Encode Justice, an international group of grassroots activists pushing for ethical uses of artificial intelligence. There have been legislators to lobby, online seminars to hold, and meetings to attend, all in hopes of educating others about the harms of facial-recognition technology.
Offshore wind machine learning and AI specialist Cognitive Business has announced the successful integration of the bathymetric tidal application on RWE?s Robin Rigg Wind Farm that will .