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Connecting enhancer variants, genes, and disease; synthetic spike binders; measuring tumors' cellular mix; and more

Posted April 9th, 2021 for Broad Institute Welcome to the April 9, 2021 installment of Research Roundup , a recurring snapshot of recent studies published by scientists at the Broad Institute and their collaborators. Enhancing V2F maps GWASs have yielded thousands of genetic variants linked to disease. To help figure out the function of many of these variants, Joseph Nasser (now at Caltech), Drew Bergman, Charles Fulco (now at Bristol Myers Squibb), Philine Guckelberger (now at...
Joseph Nasser Wendy Garrett Harvard Chan Microbiome Curtis Huttenhower Stefan Dentro Guoping Feng

Genetic diversity within tumors suggests continuous evolution

Date Time Genetic diversity within tumors suggests continuous evolution By analyzing tumors from more than 2,600 patients and from 38 cancer types, researchers from The University of Texas MD Anderson Cancer Center and fellow member institutions of the international Pan-Cancer Analysis of Whole Genomes Consortium have characterized the extensive genetic diversity across cancer and within individual tumors. The study, published today in Cell, found that 95% of the analyzed tumors had at least on...
New York United States Memorial Sloan Kettering Cancer Center United Kingdom Quaidd Morris Wenyi Wang

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