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New strategy to grow and measure how tumor organoids respond to therapy

Scientists from the UCLA Jonsson Comprehensive Cancer Center have developed a new method to bioprint miniature tumor organoids that are designed to mimic the function and architecture of real tumors. The improved process allows researchers to use an advanced imaging method to study and analyze individual organoids in great detail, which can help researchers identify personalized treatments for people with rare or hard-to-treat cancers.
United States Los Angeles Paul Boutros Nasrin Tavanaie Chuyen Nguyen Sara Sartini

Fine-tuning 3D lab-grown mini tumors to help

Scientists from the UCLA Jonsson Comprehensive Cancer Center have developed a new method to bioprint miniature tumor organoids that are designed to mimic the function and architecture of real tumors. The improved process allows researchers to use an advanced imaging method to study and analyze individual organoids in great detail, which can help researchers identify personalized treatments for people with rare or hard-to-treat cancers.
Michael Teitell Alice Soragni Ardalan Davarifar Paul Boutros Thang Nguyen Alexander Markowitz

Breast cancer-on-a-chip for testing immunotherapy drugs

Credit: Khademhosseini Lab (LOS ANGELES) - There are many mechanisms by which the body responds to foreign invaders. One of these involves the T-cells of the immune system, which have a number of different proteins on their surface called "checkpoint proteins." These checkpoint proteins bind to proteins on the surface of other cells and can result in either stimulation or suppression of T-cell activity. Normally, surface proteins on foreign or invading cells will produce a stimulation of T-c...
Jixiang Zhu Nureddin Ashammakhi Praveen Bandaru Junmin Lee Samad Ahadian Shiming Zhang

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