Digital-WGS: Automated, highly efficient whole-genome sequencing of single cells by digital microfluidics
Abstract Single-cell whole-genome sequencing (WGS) is critical for characterizing dynamic intercellular changes in DNA. Current sample preparation technologies for single-cell WGS are complex, expensive, and suffer from high amplification bias and errors. Here, we describe Digital-WGS, a sample preparation platform that streamlines high-performance single-cell WGS with automatic processing based on digital microfluidics. Using the method, we provide high single-cell capture efficiency for any a...
National Center National Natural Science Foundation Of China Innovative Research Team Of High Program For Changjiang Scholars Innovative Research Team In University Leica Microsystems Inc
Source: sciencemag.org