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Research on Novel Targets and Potential Risk Factors Drives Improvements in the Management of GI Cancers

Gastrointestinal oncology experts discuss current strategies and novel developments in gastrointestinal cancers, the role of intestinal dysbiosis and gastrointestinal carcinogenesis, germline genetic features in appendiceal cancer, and the need for anticipatory, multidisciplinary guidance in clinical practice.
United States Vanderbilt University Brianc Grieb Rajiv Agarwal Kristen Ciombor Cathy Eng

Elacestrant Highlights Promise of Oral SERDs in HR+/HER2– Metastatic Breast Cancer

Antoinette R. Tan, MD, MHSc, discusses the promise of oral selective estrogen receptor degraders as they continue to be developed for the treatment of patients with ER-positive, HER2-negative breast cancer, factors that inform treatment decisions following disease progression on a CDK4/6 inhibitor, and the growing role of antibody-drug conjugates across the breast cancer spectrum.
Arielle Heeke Neelam Desai Phasei Program At Levine Cancer Institute University Of North Carolina Department Of Medicine Atrium Health Levine Cancer Institute

VT3989 Shows Activity, Tolerability in Mesothelioma and Other NF2-Mutated Solid Tumors

VT3989, a first-in-class YAP/TEAD inhibitor, showcased durable antitumor activity and tolerability in patients with malignant mesothelioma and other solid tumors harboring NF2 mutations, according to data from a phase 1 trial presented at the 2023 AACR Annual Meeting.
United States Timothya Yap Department Of Thoracic Head University Of Texas Md Anderson Cancer Center Investigational Cancer Therapeutics Phasei Program

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Pyxis Oncology Announces Dosing of First Subject in Phase 1 Trial of PYX-201, a Novel ADC for Solid Tumors

16.03.2023 - Milestone marks transition of Pyxis Oncology to a clinical-stage company Preliminary data anticipated in early 2024 CAMBRIDGE, Mass., March 16, 2023 (GLOBE NEWSWIRE) - Pyxis Oncology, Inc. (Nasdaq: PYXS), a clinical-stage company focused on ... Seite 1
United States Alexander Spira Laras Sullivan Phasei Program Research Institute Clinical Assistant Professor At Johns Hopkins University

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