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Frontiers | Late Permian to Late Triassic Large Igneous Provinces: Timing, Eruptive Style and Paleoenvironmental Perturbations

The emplacement of the Siberian Traps, the Central Atlantic Magmatic Province (CAMP) and the Wrangellia have been linked to end-Permian, end-Triassic mass extinctions, and to the Carnian Pluvial Episode (CPE), respectively. Exploring the timing, eruptive styles, and volatile degassing of these Large Igneous Provinces (LIPs) is crucial to understand their causal link to the catastrophic environmental crises that punctuated the Triassic. In this study we review the main characteristics of these LI...
United States United Kingdom Vest Agder China General Queen Charlotte British Columbia

Frontiers | Case Report: Delayed Onset Multi-Organ Toxicities in a Melanoma Patient Achieving Complete Response to BRAF/MEK Inhibition

Autoimmune toxicities, while common following treatment with cancer immunotherapies, are not well-characterized in patients treated with BRAF/MEK inhibitors. Emerging data suggest that autoimmune effects may be linked with superior responses to both treatment modalities; however, there is little evidence describing mechanisms of immune-related toxicity for patients on BRAF/MEK inhibitors. Here we describe the experience of a 59-year-old HLA-A2, A29, B27-positive male patient with recurrent/metas...
Chiarion Sileni Yehs Vogt Koyanagi Harada Brafi Meki Homet Moreno Dummerr Development Of Encorafenib Uveitis Study Group

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