Rubella - The Lancet
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Effects of SARS-CoV-2 on prenatal lung growth assessed by fetal MRI
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Landmark SMART Study Demonstrates High Accuracy of Natera s Panorama® NIPT for 22q11 2 Deletion Screening
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Since the beginning of the COVID-19 pandemic, in-utero transmission of SARS-CoV-2 remains a rarity and only very few cases have been proven across the world. Here we depict the clinical, laboratory and radiologic findings of preterm triplets born at 28 6/7 weeks to a mother who contracted COVID-19 just one week before delivery. The triplets showed SARS-CoV-2 positivity right after birth, developed significant leukopenia and early-onset pulmonary interstitial emphysema. The most severely affected triplet I required ten days of high-frequency oscillatory ventilation due to failure of conventional invasive ventilation, and circulatory support for four days. Despite a severe clinical course in two triplets (triplet I and III), clinical management without experimental, targeted antiviral drugs was successful. At discharge home, the triplets showed no signs of neurologic or pulmonary sequelae. Placental immunohistology with SARS-CoV-2 N-protein localized strongly to syncytiotrophoblast cells