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#VisualAbstract: Seladelpar for the treatment of primary biliary cholangitis

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Minute medicine incAlkaline phosphataseBile ductPpar agonistPpard agonistPrimary biliary cholangitis

RESPONSE: Seladelpar Normalizes Alkaline Phosphatase, Reduces Pruritus in PBC

Results from the phase 3 trial showed seladelpar elicited biochemical response, normalized alkaline phosphatase, and reduced pruritus at a greater rate than placebo.

David assisTerry hornerGideon hirschfieldYale school of medicineAutoimmune liver disease researchDrug administrationUniversity of torontoFoundation gideon hirschfieldNew england journalYale schoolCymabay therapeutic new drug applicationPriority reviewPrescription drug user fee actTerry horner chairPrimary biliaryImproves markers

Tharimmune, Inc : Tharimmune Announces Positive Results in Phase 1 Clinical Trial of TH104, its Lead Clinical Therapeutic Candidate

Tharimmune, Inc : Tharimmune Announces Positive Results in Phase 1 Clinical Trial of TH104, its Lead Clinical Therapeutic Candidate
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United statesRandy milbyNational institutes of healthCompany phaseExchange commissionOmniab incTharimmune incNational institute of diabetesChief executive officerPrimary biliary cholangitisNational instituteKidney diseasesNational institutesPrivate securities litigation reform actRisk factorsAnnual report

Tharimmune Announces Positive Results in Phase 1 Clinical Trial of TH104, its Lead Clinical Therapeutic Candidate

Tharimmune Announces Positive Results in Phase 1 Clinical Trial of TH104, its Lead Clinical Therapeutic Candidate
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United statesNova scotiaRandy milbyNational institutes of healthExchange commissionNational institute of diabetesOmniab incTharimmune incCompany phaseAnnounces positive resultsLead clinical therapeuticChief executive officerPrimary biliary cholangitisNational instituteKidney diseasesNational institutes

Itch a wrap: Cymabay PBC story ends with $4 3B Gilead buy

Seeking to rejuvenate itself after recent disappointments, Gilead Sciences Inc. proposes to bolster its liver portfolio by taking over Cymabay Therapeutics Inc. for $32.50 per share in cash, a total equity value of $4.3 billion. The arrangement brings aboard seladelpar for second-line primary biliary cholangitis (PBC) including pruritis (itch), which is under priority review by the U.S. FDA, with a decision due this year.

Gilead sciences incCymabay therapeutics incGilead sciencesCymabay therapeuticsGilead sciences incCymabay therapeutics incPrimary biliary cholangitisDeals andm amp a