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 E-Mail Researchers at the Garvan Institute of Medical Research have discovered a new type of bone cell that may reveal new therapeutic approaches for osteoporosis and other skeletal diseases. The new cells, which the researchers term osteomorphs , are found in the blood and bone marrow, and fuse together to form osteoclasts, specialised cells that break down bone tissue. They have a unique genomic profile that reveals promising and as yet unexplored targets for therapy. This discovery is a game-changer, which not only helps us understand bone biology but presents significant new in-roads for osteoporosis therapy, says co-senior author Professor Tri Phan, who heads the Intravital Microscopy and Gene Expression Lab at the Garvan Institute. Osteomorphs express several genes that seem to be linked to bone disease, which could lead scientists to entirely new ways to target osteoporosis.

City ofUnited kingdomUnited statesNew south walesTri phanJanice gibsonMichelle mcdonaldWeng hua khooPeter croucherGarvan instituteNational healthBone biology labBone microenvironment group at garvanUniversity of queenslandUniversity of sydneyGarvan institute of medical research