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Researchers find novel inhibitors that may suppress oncogenesis of metastatic prostate cancer

Researchers have found that treating prostate cancer cells with novel cyclin-dependent kinase 19 (CDK19) and homologous cyclin-dependent kinase 8 (CDK8) inhibitors reduces their potential to migrate into and invade surrounding structures.
United States Sven Perner Emily Henderson Leibniz Lung Center Institute Of Pathology University Hospital Schleswig Holstein

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New study reveals oral opaganib's potent in vitro activity against Omicron

RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced study results in which opaganib (ABC294640), a leading oral drug candidate for hospitalized patients with moderate to severe COVID-19, was observed to have potent in vitro efficacy against the Omicron SARS-CoV-2 variant, while maintaining host cell viability.
North Somerset United Kingdom Michael Chan Reza Fathi Emily Henderson Us National Institute Of Health

Aptevo Therapeutics: APVO442 Prostate Cancer Data Presented at the American Association for Cancer Research Annual Meeting

Preclinical Data Support Potential for APVO442 in Difficult-to-Treat Types of Prostate Cancer, Including Metastatic Castration-Resistant DiseaseSEATTLE, WA / ACCESSWIRE / April 12, 2022 / Aptevo Therapeutics
United States Michelle Nelson Miriam Weber Miller Exchange Commission American Association For Cancer Research Aptevo Therapeutics Inc

Drugs targeting DNA damage response pathway show therapeutic potential against advanced solid tumors

Results from early-stage clinical trials show two drugs that target the DNA damage response (DDR) pathway in cancers -; ATR inhibitor elimusertib and PARP inhibitor AZD5305 -; are safe and clinically beneficial in treating patients with advanced solid tumors.
United States Timothy Yap Emily Henderson American Association For Cancer Research Investigational Cancer Therapeutics American Association

Researchers pinpoint rural Georgia counties as hotspots for death from four common cancers

Georgia counties with the highest mortality rates from four common cancers tended to be more rural, have higher poverty rates, have a higher percentage of Black residents and/or older individuals, according to researchers at the state's public medical school and Georgia Cancer Center.
United States Glascock County Warren County Miller County Richmond County Jenkins County

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