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Constant exposure of cells to stressing agents, such as pathogens, may disturb an organism's normal functioning. To fight stress, cells have developed several coping mechanisms, including the inflammatory response.

In a new paper published in Science, EMBL Grenoble researchers provide essential insights on the molecular activation of the MAP kinase p38α, the final switch triggering the inflammatory response. Inflammation is a cellular coping mechanism when confronted with stress, such as an infection. However, too much inflammation can damage the functioning of cells and organs. This is the case with cytokine storms, inflammatory cascades that can lead to severe disease and death, recently highlighted dur...

With the development of accurate protein structure prediction algorithms, artificial intelligence (AI) has emerged as a powerful tool in the field of structural biology. AI-based algorithms have been used to analyze large amounts of protein sequence data including the human proteome, complementing experimental structure data found in resources such as the Protein Data Bank. The EBI AlphaFold Protein Structure Database (for example) contains over 230 million structures. In this study, these data ...

To quickly direct the development of new antiviral therapy against SARS-CoV-2 and its emerging variants

Access to the 3D-mapping AlphaFold technology is having a major impact on research into antibodies and disease treatments

Evaluating the anti-cancer efficacy of Chitosan nanoparticles loaded with hGH fragment 176–191 peptide plus the clinical chemotherapeutic doxorubicin. Read more

Researchers used the SARS-CoV-2 sequence against aptamers to perform the in silico selection of an aptamer against the SARS-CoV-2 S protein.

Cyanobacteria have evolved complicated mechanisms to transform light energy into chemical energy during three billion years of existence. Cyanobacteria produce reducing power (NADPH) and chemical energy (ATP) for carbon dioxide fixation using only the most basic of ingredients: light and water.

The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic due to the high transmission and mortality rate of this virus. The world health and economic sectors have been severely affected by this deadly virus, exacerbated by the lack of sufficient efficient vaccines. The design of effective drug candidates and their rapid development is necessary to combat this virus. In this study, we selected 23 antimicrobial peptides from the literature and predicted thei...

In a new study published in the journal Pathogens, researchers have summarized the role of the macrodomain in viral replication and virulence and further reviewed the development of macrodomain inhibitors as antiviral agents.