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The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA during infection, cancer and inflammatory disease, and initiates potent innate immune responses through the synthesis of 2′3′-cyclic GMP-AMP (cGAMP)1–7. The indiscriminate activity of cGAS towards DNA demands tight regulatory mechanisms that are necessary to maintain cell and tissue homeostasis under normal conditions. Inside the cell nucleus, anchoring to nucleosomes and competition with chromatin architectural proteins jointl...
Cytiva Akt Lipofectamine Rnai Jackson Immunoresearch Microplates Perkin Elmer Q Exactive Orbitrap Phenoplate Perkinelmer
Source: nature.com

Investegate |Olink Proteomics AB Announcements | Olink Proteomics AB: Erasmus Medical Center, Rotterdam is partnering with Olink to deepen understanding of disease progression and accelerate the development of novel therapies

Investegate announcements from Olink Proteomics AB, Erasmus Medical Center, Rotterdam is partnering with Olink to deepen understanding of disease progression and accelerate the development of novel therapies
Zuid Holland United States Uppsala Lan Andrea Prander Joyce Van Meurs Jan Medina

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ALSA Ventures Launches Promatix to Develop Next Generation Novel Oncology Therapeutics

Search jobs ALSA Ventures Launches Promatix to Develop Next Generation Novel Oncology Therapeutics LONDON--(BUSINESS WIRE)--ALSA Ventures today announced the launch of Promatix Inc., a Delaware incorporated company, to develop novel therapeutics with the potential to transform the treatment of cancer. Promatix will use its multi-omic proprietary database, TxPro, to mine for novel, and validate existing, drug targets. “As we mark off the 20 th anniversary of drafting t...
United States United Kingdom City Of Katie Sunnucks Jasmin Fisher Namshik Han

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