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Unexpected Protein Could Play Role Frontotemporal Dementia

Amyloid fibrils in those with frontotemporal lobar degeneration (FTLD) contain a little-known protein called TMEM106B. Researchers speculate TMEM106B could be found to be the cause of FTLD.

Little-known protein found to play a role in common neurodegenerative disorder

Scientists have known for years that amyloid fibrils -; fibrous, ropelike structures formed by closely linked protein molecules -; are present in the brains of patients with Alzheimer's and Parkinson's diseases and likely play a role in the progression of these disorders.

Unexpected protein could play role in common brain disorder

Unexpected protein could play role in common brain disorder
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Potential Protective Role for Protein in Alzheimer s Disease

Read Time: A protein that wreaks havoc in the nerves and heart when it clumps together can prevent the formation of toxic protein clumps associated with Alzheimer’s disease, a new study led by a UT Southwestern researcher shows. The findings, published recently in the  Journal of Biological Chemistry, could lead to new treatments for this brain-ravaging condition, which currently has no truly effective therapies and no cure. Researchers have long known that sticky plaques of a protein known as amyloid beta are a hallmark of Alzheimer’s and are toxic to brain cells. As early as the mid-1990s, other proteins were discovered in these plaques as well.

Protein that can be toxic in the heart and nerves may help prevent Alzheimer s

 E-Mail IMAGE: Abnormal deposits of the protein amyloid beta in the brain have been linked to Alzheimer s disease. The above illustration reveals a potential way discovered by UTSW researchers to stop this. view more  Credit: UT Southwestern Medical Center DALLAS - Jan. 7, 2020 - A protein that wreaks havoc in the nerves and heart when it clumps together can prevent the formation of toxic protein clumps associated with Alzheimer s disease, a new study led by a UT Southwestern researcher shows. The findings, published recently in the Journal of Biological Chemistry, could lead to new treatments for this brain-ravaging condition, which currently has no truly effective therapies and no cure.

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