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New deep-learning framework predicts gene regulation at single-cell level Scientists at the University of California, Irvine have developed a new deep-learning framework that predicts gene regulation at the single-cell level. Deep learning, a family of machine-learning methods based on artificial neural networks, has revolutionized applications such as image interpretation, natural language processing and autonomous driving. In a study published recently in Science Advances, UCI researchers describe how the technique can also be successfully used to observe gene regulation at the cellular level. Until now, that process had been limited to tissue-level analysis. According to co-senior author Xiaohui Xie, UCI professor of computer science, the framework enables the study of transcription factor binding at the cellular level, which was previously impossible due to the intrinsic noise and sparsity of single-cell data. A transcription factor is a protein that controls the translation

United statesXiaohui xieEmily hendersonSimons centerUniversity of californiaMultiscale cell fate researchNational science foundationScience advancesQing nieNational science foundation simons centerDeep learningஒன்றுபட்டது மாநிலங்களில்எமிலி ஹென்டர்சன்சிமன்கள் மையம்பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியாதேசிய அறிவியல் அடித்தளம்