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Frontiers | Stiffening of Circumferential F-Actin Bands Correlates With Regenerative Failure and May Act as a Biomechanical Brake in the Mammalian Inner Ear

The loss of inner ear hair cells causes permanent hearing and balance deficits in humans and other mammals, but nonmammals recover after supporting cells (SCs) divide and replace hair cells. The proliferative capacity of mammalian SCs declines as exceptionally thick circumferential F-actin bands develop at their adherens junctions. We hypothesized that the reinforced junctions were limiting regenerative responses of mammalian SCs by impeding changes in cell shape and epithelial tension. Using mi...
United States Noord Holland Zeiss Axiovert Cingulin Zymed Martin Pollak Kos White Leghorn

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Bruker introduces fast BioAFM for automated mechanobiology

Bruker today announced the release of the JPK NanoWizard® V BioAFM, a novel system that marks a milestone in automation and ease of use for life science atomic force microscopy research. NanoWizard V is a very fast, automated BioAFM that can optionally be fully integrated with advanced optical microscopes.
New South Wales Nanowizardv Bio Bruker Nano Surfacesdec David Martinez Martin Martinez Martin Heiko Haschke

Weight-bearing CT, 3D analysis can assess knee osteoarthritis

Using internally developed 3D image visualization software, a multinstitutional team of researchers led by Dr. Tom Turmezei, PhD, of Norfolk and Norwich University Hospitals NHS Foundation Trust in the U.K. found that 3D maps of the knee joint space width distribution correlated highly with structural joint disease. Taking less than 10 minutes to perform, the method was feasible and reproducible, detecting joint space width differences as low as ± 0.1 mm. "It is reliably learned by novice use...
Tom Turmezei Frank Roemer Friedrich Alexander University Erlangen Norwich University Hospitals Multicenter Osteoarthritis Friedrich Alexander University Erlangen N

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