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Fast-track rehabilitation after THR yielded shorter stays, better functional outcomes

Patients who received fast-track rehabilitation after total hip replacement experienced shorter hospital stays and better functional outcomes compared with patients who had conventional rehabilitation, according to results.Researchers randomly assigned 60 patients undergoing THR for hip arthritis to participate in conventional rehabilitation after a normal hospital stay or a fast-track
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Source: healio.com

Those with psychiatric illness less likely to be tested, vaccinated than general population

Those hospitalized for psychiatric illness were less likely to be tested for COVID-19 and had lower confirmed infection rates but higher risk for COVID-19-related mortality than the general population, per a study from Molecular Psychiatry. “Many authors have recommended prioritization of COVID-19 vaccination for people with severe mental illness, and some but not all studies reported lower
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Source: healio.com

Ibrutinib shows promise for children with chronic graft-versus-host disease

SALT LAKE CITY — Ibrutinib appeared safe and effective for children with previously untreated or relapsed/refractory chronic graft-versus-host disease, according to study results. Paul A. Carpenter, MD, professor at Fred Hutchinson Cancer Research Center, presented the results at Tandem Meetings | Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR.
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Source: healio.com

FDA approves mavacamten, first treatment for obstructive hypertrophic cardiomyopathy

The FDA approved mavacamten for the treatment of symptomatic, obstructive hypertrophic cardiomyopathy, the first cardiac myosin inhibitor to be permitted for use in the United States, Bristol Myers Squibb announced.Mavacamten (Camzyos, Bristol Myers Squibb) is the first and only FDA-approved allosteric and reversible inhibitor selective for cardiac myosin that targets the underlying
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Source: healio.com

Factors predict survival after immunotherapy combination for HNSCC

DALLAS — Multiple factors predicted improved survival among patients with head and neck or salivary gland cancers treated with pembrolizumab plus vorinostat, according to prospective study results.Patients with lower pretreatment neutrophils and neutrophil-to-lymphocyte ratios — as well as those with more pretreatment lymphocytes and T helper cells — achieved longer OS and PFS,
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Source: healio.com

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FDA proposes rules prohibiting menthol cigarettes, flavored cigars

The FDA proposed prohibiting menthol cigarettes and flavored cigars. The new product standards are designed to substantially prevent disease and death from combusted product use and to prevent young people from starting to smoke.“The proposed rules would help prevent children from becoming the next generation of smokers and help adult smokers quit,” HHS Secretary Xavier Becerra said
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Source: healio.com

Targeted sequencing promising for molecular profiling of HNSCC

DALLAS — Targeted sequencing appears to be a promising strategy for molecular profiling of head and neck squamous cell carcinoma, according to study results.The findings — presented at American Head & Neck Society Annual Meeting — showed a correlation between detection of circulating tumor DNA (ctDNA) and pathological adverse features.
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Source: healio.com

Enhertu receives breakthrough therapy designation for breast cancer subset

The FDA granted breakthrough therapy designation to fam-trastuzumab deruxtecan-nxki for treatment of adults with unresectable or metastatic HER2-low breast cancer, according to a press release from the agent’s manufacturer.The designation applies to use of the HER2-directed antibody-drug conjugate by patients who previously received a systemic therapy in the metastatic setting or
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Source: healio.com

Mystery outbreak of severe hepatitis in children prompts worldwide surveillance

The WHO has reported at least 169 cases of severe, acute hepatitis in children aged 1 month to 16 years from a dozen countries worldwide, according to a statement from the organization. According to WHO, one child has died and 17 children have received liver transplantation as a result of the disease. As of April 21, 114 cases have been reported in the United Kingdom, followed by Spain (13),
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Source: healio.com

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