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Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial | Critical Care Medicine | JAMA

This randomized clinical trial compares the effect of continuous positive airway pressure or high-flow nasal oxygen vs conventional oxygen therapy on clinical o

United kingdomEteläuomen läiBrighton and hoveEast sussexWest midlandsUnited kingdom generalNorthern irelandCity ofDanielf mcauleyEli lillyQueen university belfastDevelopment divisionBoehringer ingelheimMidlands research design serviceWellcome wolfson institute for experimental medicineBritish heart foundation

Impact of the coronavirus disease 2019 interventions on the incidence of hand, foot, and mouth disease in mainland China

Impact of the coronavirus disease 2019 interventions on the incidence of hand, foot, and mouth disease in mainland China
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United statesXi chenJyue chenZhaorui changFengfeng liuZheng zhaoQing suZhijie zhangMinrui renJiaxu leJiaqi huangHongchao qiJianbo baZhongjie liJie hongCanjun zheng

Combination of tucatinib and neural stem cells secreting anti-HER2 antibody prolongs survival of mice with metastatic brain cancer

Brain metastases are among the most severe complications of systemic breast cancer, and overexpression of the human epidermal growth factor receptor 2 (HER2) in breast cancer cells increases the incidence of brain metastases in patients. In this study, we engineered the human-derived, tumor cell tropic neural stem cells LM-NSC008 (LM008) to continuously secrete antibodies against HER2. These anti-HER2 antibodies impaired tumor cell proliferation by inhibiting the PI3K-Akt signaling pathway in HER2+ breast cancer cells in vitro. Importantly, our results demonstrate that the therapeutic combinatorial regimen consisting of LM-NSC008 anti-HER2 antibody-secreting cells and the HER2 kinase inhibitor tucatinib provide therapeutic benefit and prolong survival in preclinical models of HER2+ breast cancer brain metastases.

United statesHarvard universityGlo promegaTrastuzumab herceptinYu hanTucatinib tukysaDihua yuEbioscience foxpAurora lopez rosasGraphpad software incL heparin stemcell technologyBecton dickinsonDrug administrationMd anderson cancer centerThermo fisherDihua yu md anderson cancer center

Vaccine effectiveness against SARS-CoV-2 infection, hospitalization, and death when combining a first dose ChAdOx1 vaccine with a subsequent mRNA vaccine in Denmark: A nationwide population-based cohort study

Mie Agermose Gram and co-workers study the effectiveness of heterologous SARS-CoV-2 vaccine combinations in the Danish population.

Netherlands generalUnited kingdomOxford astrazenecaMirjamee kretzschmarDanish data protection agencyDanish health data authorityDanish health authorityInternational classification of diseasesDanish national patient registryDepartment of data integrationR foundation for statistical computingCoronavirus diseaseSevere acute respiratory syndrome coronavirusDanish civil registrationUniversitair medisch centrum utrechtCreative commons attribution license

Extensively Drug-Resistant Carbapenemase-Producing Pseudomonas aeruginosa and Medical Tourism from the United States to Mexico, 2018–2019

Extensively Drug-Resistant Carbapenemase-Producing Pseudomonas aeruginosa and Medical Tourism from the United States to Mexico, 2018–2019
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