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RNA-DNA World Circumvents RNA World Sticking Point December 31, 2020 Even those who doubt the RNA World hypothesis may be hard-pressed to argue against it. Consider the predicament faced by a team of scientists at Scripps Research. They suspected that RNA was a poor candidate for life chemistry’s original self-replicating molecule. RNA, they believed, was simply too sticky. That is, they thought that complementary RNA strands in the primordial ooze would have had a hard time separating because strand-separating enzymes would not have existed yet. And yet these same scientists had found that an organic compound called diamidophosphate (DAP) a compound that could have been present in the ooze could have played a crucial role in modifying ribonucleosides and stringing them together into the first RNA strands. This finding didn’t necessarily favor the RNA World hypothesis. In fact, it was, potentially, compatible with the RNA-DNA World hypothesis, which the Scripps Research team f

Ramanarayanan krishnamurthyEddy jimAngewandte chemieScripps researchConcomitant oligomerizationஎடி ஜிம்ஸ்கிரிப்ட்கள் ஆராய்ச்சி