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Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology

Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology
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Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study

Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study
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A COVID-fighter s guide to T cells

Credit: CDC LA JOLLA In a new paper, scientists from La Jolla Institute for Immunology (LJI) bring together research findings from COVID-19 researchers around the world. The results are striking: human T cells can target more than 1,400 sites on the SARS-CoV-2 virus. Our lab and many others have shown this very broad and diverse T cell response, says LJI Research Assistant Professor Daniela Weiskopf, Ph.D., co-author of the Cell Host & Microbe review. This kind of research review, called a meta-analysis, pools the results of multiple studies, and the researchers give close consideration to how the studies were conducted. In the case of COVID-19, a global meta-analysis of T cell response studies is especially helpful because different patient populations can have vastly different immune responses, based on their genetic differences and past disease history.

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