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2nd generation CD40L blocker safely reduces new brain lesions in Phase 2 trial | Frexalimab may help reduce MS activity with fewer side effects: Trial data

Frexalimab, a second-generation CD40L blocker, safely reduced the number of new active brain lesions in relapsing MS patients in a Phase 2 trial.
United States Erik Wallstr Gavin Giovannoni Consortium Of Multiple Sclerosis Center London School Of Medicine Queen Mary University Of London

AbbVie's RINVOQ® (upadacitinib) Met Primary and All Ranked Secondary Endpoints in Phase 3 Study in Ankylosing Spondylitis

/PRNewswire/ -- AbbVie (NYSE: ABBV) today announced positive top-line results from the first of two studies of the Phase 3 SELECT-AXIS 2 clinical trial...
Michael Severino European Commission Drug Administration Exchange Commission Spondyloarthritis Research Consortium Of Canada Assessment In Spondyloarthritis International Society

AbbVie's Upadacitinib Met Primary and Most Ranked Secondary Endpoints in Phase 3 Study for Non-Radiographic Axial Spondyloarthritis

ABBVie today announced positive top-line results from Study 2 of the Phase 3 SELECT-AXIS 2 clinical trial in adults with active non-radiographic axial spondyloarthritis showing upadacitinib met the primary endpoint of Assessment in SpondyloArthritis International Society 40 response and the majority of ranked secondary endpoints at week 14. 1 Significantly more upadacitinib-treated patients achieved ASAS40 ...
United States Michael Severino European Commission Drug Administration Rheumatic Diseases At Oregon Health Science University Exchange Commission

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AbbVie's Upadacitinib (RINVOQ®) Met Primary and Most Ranked Secondary Endpoints in Phase 3 Study for Non-Radiographic Axial Spondyloarthritis

/PRNewswire/ -- AbbVie (NYSE: ABBV) today announced positive top-line results from Study 2 of the Phase 3 SELECT-AXIS 2 clinical trial in adults with active...
Michael Severino European Commission Drug Administration Exchange Commission Assessment In Spondyloarthritis International Society Abbvie Deutschland Gmbh Co

AbbVie to Present Analysis Evaluating Continuous RINVOQ® (upadacitinib) Treatment in Psoriatic Arthritis for More Than One Year at EULAR 2021 Virtual Congress

AbbVie to Present Analysis Evaluating Continuous RINVOQ® (upadacitinib) Treatment in Psoriatic Arthritis for More Than One Year at EULAR 2021 Virtual Congress - In SELECT-PsA 2, 29 percent of bDMARD-IR patients treated with continuous RINVOQ (upadacitinib, 15 mg, once daily) achieved minimal disease activity at 56 weeks, which was consistent with improvements from baseline seen at week 24[1],[2] - The safety results of RINVOQ 15 mg were consistent with previously reported results in rheumatoid...
Clin Rheumatol Philip Mease Mudra Kapoor Prnewswire Abbvie Exchange Commission Joseph Health

AbbVie to Present Analysis Evaluating Continuous RINVOQ® Treatment in Psoriatic Arthritis for More Than One Year at EULAR 2021 Virtual Congress

ABBVie  today announced results of an analysis from the Phase 3 SELECT-PsA 2 clinical trial, showing that continuous treatment with RINVOQ ® resulted in sustained improvements in disease activity for more than one year among patients with active psoriatic arthritis who have responded inadequately to one or more biologic disease modifying anti-rheumatic drugs . 1 At week 56, 29 percent of patients treated with ...
Clin Rheumatol Philip Mease Mudra Kapoor Exchange Commission Joseph Health European Commission

Transgene Expands Phase II Clinical Trial of Therapeutic Vaccine TG4001 in Combination With Avelumab Versus Avelumab Monotherapy in Patients With HPV16-positive Anogenital Cancers

Transgene Expands Phase II Clinical Trial of Therapeutic Vaccine TG4001 in Combination With Avelumab Versus Avelumab Monotherapy in Patients With HPV16-positive Anogenital Cancers - Trial will focus on patients without liver metastases, based on encouraging data in Phase Ib/II study - Trial targets indications where clinical outcomes can be improved versus standard therapeutic options and immune checkpoint inhibitors ("ICIs") - Continued clinical collaboration with Merck KGaA, Darmstadt, Ger...
Distrito Federal United States United Kingdom Lucie Larguier Christophe Le Tourneau Le Tourneau

Helsinn announces publication of latest mechlorethamine gel research, highlighting its efficacy ...

Press release content from Globe Newswire. The AP news staff was not involved in its creation. Helsinn announces publication of latest mechlorethamine gel research, highlighting its efficacy ... Helsinn Healthcare S.A.February 18, 2021 GMT Helsinn announces publication of latest mechlorethamine gel research, highlighting its efficacy and safety Lugano, Switzerland, February 18, 2021 – Helsinn, a Swiss pharmaceutical group focused on building quality cancer care and rare disease products, is p...
Williaml Bailey Larisaj Geskin Paola Bonvicini Helsinn Investment Fund Helsinn Therapeutics Us Inc Swiss Pharma Company
Source: apnews.com

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