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Evaluation of point-of-care multiplex polymerase chain reaction in guiding antibiotic treatment of patients acutely admitted with suspected community-acquired pneumonia in Denmark: A multicentre randomised controlled trial

In this multicentre randomised controlled trial, Mariana Bichuette Cartuliares and colleagues evaluate point-of-care multiplex polymerase chain reaction in antibiotic treatment of patients acutely admitted with suspected community-acquired pneumonia in Denmark.
Eteläuomen Läi United States Caroline Moos Jean Louis Vincent Kresten Philipsensvej National Health Data Agency
Source: plos.org

Surgery with locking plate or hemiarthroplasty versus nonoperative treatment of 3–4-part proximal humerus fractures in older patients (NITEP): An open-label randomized trial

In a randomized controlled trial, Antti P Launonen and team compare outcomes of non-operative to operative treatment in patients aged ≥ 60 years with 3-4 part dislocated proximal humerus fractures.
Kanta Hame Region Central Finland Keski Suomi Norra Savolax Uppsala Lan Eteläuomen Läi
Source: plos.org

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Exercise and aerobic capacity in individuals with spinal cord injury: A systematic review with meta-analysis and meta-regression

In this systematic review with meta-analysis and meta-regression, Daniel D. Hodgkiss and colleagues investigate exercise and aerobic capacity in individuals with spinal cord injury.
International Standards For Neurological Classification International Stoke Mandeville Games Federation Or Frankel International Stoke Mandeville Games Federation International Standards Neurological Classification Intervention Description
Source: plos.org

"Participant Safety in Multisite, Randomized, Double-Blind, Placebo-Con" by David C. Currow, Belinda Fazekas et al.

Objective: To describe the harms in all arms of six consecutive multi-site, double-blind, placebo-controlled randomised clinical trials. Background: Controversies surround conduct of phase III clinical trials in palliative care. Concerns include risks to participants' safety, use of placebo arms, participants' burden, and justification when therapies are already widely used. Methods: This study collates safety data of the first six studies of the Australian national Palliative Care Cli...
Palliative Care Clinical Studies Adverse Events Palliative Care Articipant Withdrawal Rates Randomized Controlled Trials Symptom Control
Source: uow.edu.au

Frequency of multiple changes to prespecified primary outcomes of clinical trials completed between 2009 and 2017 in German university medical centers: A meta-research study

In this meta-research study, Martin Holst and colleagues investigate changes to prespecified primary outcomes in the historic registries of clinical trials.
Research Of Germany Bundesministerium Ministry Of Education Drug Administration Amendments German Clinical Trials Register Open Science Framework Creative Commons Attribution License
Source: plos.org

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