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DNAstack Unveils Viral AI for Genomic Variant Surveillance and Infectious Disease Research

DNAstack today announced Viral AI, a federated network for genomic variant surveillance and infectious disease research. Viral AI was designed to deliver equitable access to software infrastructure, accelerate international data sharing, and empower scientists and public health officials with globally representative datasets they need to mitigate current and future infectious disease outbreaks.
Laura Thomsonfeb David Glazer Oxford Nanopore Maggie Carter Peter Goodhand Catalina Lopez Correa

Frontiers | Lentinan Supplementation Protects the Gut–Liver Axis and Prevents Steatohepatitis: The Role of Gut Microbiota Involved

The microbiota-gut-liver axis has emerged as an important player in developing non-alcoholic steatohepatitis (NASH), a type of non-alcoholic fatty liver disease (NAFLD). Higher mushroom intake is negatively associated with the prevalence of NAFLD. This study examined whether lentinan, an active ingredient in mushroom, could improve NAFLD and gut microbiota dysbiosis in NAFLD mice induced by a high-fat (HF) diet. Dietary lentinan supplementation for 15 weeks significantly improved gut microbiota ...
United States South Korea J Physiol Gastrointest Clin Biochem Wuy Mito Nutr Biochem

Frontiers | A Novel Probable Pathogenic PSEN2 Mutation p.Phe369Ser Associated With Early-Onset Alzheimer's Disease in a Chinese Han Family: A Case Report

Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China The pathogenesis of Alzheimers disease is complex, and early-onset Alzheimers disease (EOAD) is mostly influenced by genetic factors. Presenilin-1, presenilin-2 (PSEN2), and amyloid precursor protein are currently known as the three main causative genes for autosomal dominant EOAD, with the PSEN2 mutation being the rarest. In this study, we reported a 56-year-old Chinese Han proband who presented wi...
United Kingdom United States San Diego Ultrasonicator Covaris Silva Lopes Alzheimers Dement

American professor reveals China deleted patient samples, confirms coronavirus was already spreading before "official" timeline

Despite evidence that shows the coronavirus (COVID-19) pandemic was actually a “plandemic,” China continues to deny that it orchestrated the virus’ spread across the globe. But thanks to the efforts of an American professor, the world now has more proof that the coronavirus originated from a lab as a biological weapon, not from bats. According to Professor Jesse Bloom, China deleted patient samples that prove how the coronavirus was already circulating in Wuhan before China’s alleged...
United States United Kingdom Patrick Vallance Anthony Fauci Tedros Adhanom Ghebreyesus Dominic Cummings

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NIH defends deleting COVID-19 genetic data pointing to lab leak origin

Print this article The National Institutes of Health defended its decision to delete its record of the genetic sequencing of COVID-19 cases from early in the coronavirus pandemic, apparently done at the request of Chinese researchers. The revelation was revealed by a U.S. virologist who discovered the information was scrubbed from the NIH database. This comes as the United States and its allies seek to determine if the virus sprang from a mysterious lab in Wuhan, China, which stymied an earl...
United States Francis Collins Anthony Fauci Richard Ebright Josh Hawley A State Department

Chinese scientists deleted key data that could help identify origins of COVID-19, study claims

An American scientist recovered the deleted data from cloud storage and published his analysis Tuesday. The paper, “Recovery of deleted deep sequencing data sheds more light on the early Wuhan SARS-CoV-2 epidemic,” suggests that early virus samples from the Wuhan seafood market that until now have been the focus of most studies on the origins of the pandemic “are not fully representative of the viruses actually present in Wuhan at that time.” The paper is not yet peer-reviewed, and ...
United States Dan Le Batard Rasmus Neilsen Jason Whitlock Jemele Hill Colin Cowherd

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes

Most analyses of the antibody responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have focused on antibodies cloned from memory B cells. This approach has led researchers to conclude that neutralizing antibodies (nAbs) primarily target the receptor-binding domain (RBD) of the viruss spike protein. Voss et al. took a different approach, using proteomic deconvolution of the serum immunoglobulin G antibody repertoire from four COVID-19 convalescent patients. ...
United States San Francisco University Of California Lamontagne Center Ut System Proteomics Network National Institute Of Allergy

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