Set in 1999 in a small hospital in Arkansas
12 Hour Shift follows junkie nurse Mandy (Angela Bettis) who is making extra money selling organs of dying patients whose demise she speeds along. But, when her cousin Regina (Chloe Farnworth) misplaces a kidney – which local gangster Nick (Mick Foley) was going to buy – Mandy finds herself having to acquire a fresh one during a 12-hour shift. Chaos descends when Regina insists on helping in lethal ways and a wounded murderer (Arquette) breaks loose.
We spoke to actor David Arquette about filming the comedy horror in an abandoned hospital and what it’s been like working as an actor for 30 years…