Page 7 - Regulation Program News Today

Credit: The Wistar Institute PHILADELPHIA -- (March 12, 2021) -- Scientists at The Wistar Institute identified a new function of ADAR1, a protein responsible for RNA editing, discovering that the ADAR1p110 isoform regulates genome stability at chromosome ends and is required for continued proliferation of cancer cells. These findings, reported in Nature Communications, reveal an additional oncogenic function of ADAR1 and reaffirm its potential as a therapeutic target in cancer. The lab of Kaz...

Credit: The Wistar Institute PHILADELPHIA -- (Jan. 21, 2021) -- Researchers at The Wistar Institute have discovered a new enzymatic function of the Epstein-Barr Virus (EBV) protein EBNA1, a critical factor in EBVs ability to transform human cells and cause cancer. Published in Cell, this study provides new indications for inhibiting EBNA1 function, opening up fresh avenues for development of therapies to treat EBV-associated cancers. EBV establishes life-long, latent infection in B lymphocyte...

EGR1 Inhibits Pro-Inflammatory Gene Expression in Macrophages January 14, 2021 Researchers at The Wistar Institute say they have discovered that Early Growth Response 1 (EGR1), a protein that turns on and off specific genes during blood cell development, inhibits expression of pro-inflammatory genes in macrophages. As part of their function to protect the body against pathogens, macrophages play a major role in initiation, maintenance, and resolution of inflammation. The discovery expands the u...

EGR1 protein acts as a master regulator of inflammation in macrophages, study suggests Scientists at The Wistar Institute discovered that Early Growth Response 1 (EGR1), a protein that turns on and off specific genes during blood cell development, inhibits expression of pro-inflammatory genes in macrophages. As part of their function to protect the body against pathogens, macrophages play a major role in initiation, maintenance, and resolution of inflammation. The discovery expands the understa...

Here, ed. hes been given a free shot to rail against the republicans. and every time an irrelevant light weight republican type like eric cantor starts talking stupid talk, it failed us for two decades now. americans are gagging on this republican talking point that billionaires or patriots who care about job creation. if we let them get away with their tax scams, if we let them get away with the tax shelter, theyre going to take that money and give it to the american working public. weve seen i...

Obama has been given a free shot here, ed. hes been given a free shot to rail against the republicans. and every time an irrelevant light weight republican type like eric cantor starts talking stupid talk, it failed us for two decades now. americans are gagging on this republican talking point that billionaires or patriots who care about job creation. if we let them get away with their tax scams, if we let them get away with the tax shelter, theyre going to take that money and give it to the ame...