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Mirtazapine added to SSRIs or SNRIs for treatment resistant depression in primary care: phase III randomised placebo controlled trial (MIR)

Objective To investigate the effectiveness of combining mirtazapine with serotonin-noradrenaline reuptake inhibitor (SNRI) or selective serotonin reuptake inhibitor (SSRI) antidepressants for treatment resistant depression in primary care. Design Two parallel group multicentre phase III randomised placebo controlled trial. Setting 106 general practices in four UK sites; Bristol, Exeter, Hull, and Keele/North Staffs, August 2013 to October 2015. Participants 480 adults aged 18 or more years who s...
United Kingdom Caroline Jenkinson Mary Carter Ianm Anderson Dalan Montgomery Marie Platt
Source: bmj.com

People with depression often excluded from clinical studies of antidepressants?

2009 report posted for filing Contact: Clare Collins CollCX@upmc.edu 412-647-3555 University of Pittsburgh Schools of the Health Sciences Are we cherry picking participants for studies of antidepressants? People with depression often excluded from clinical studies and tend not to fare as well as study participants PITTSBURGH, April 28 – Findings from clinical studies used to…
United States Madhukar Trivedi Clare Collins James Luther Bradley Gaynes Philip Lavori

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