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Comparative adjuvant trial evaluates Army-developed ALF in HIV vaccine regimens

 E-Mail IMAGE: A clinician with the Kenya Medical Research Institute/Walter Reed Project Clinical Research Center administers an injection to a participant of a comparative adjuvant trial, RV460. view more  Credit: U.S. Military HIV Research Program SILVER SPRING, Md. - A new Phase 1 vaccine study began today that will evaluate experimental prime/boost HIV-1 vaccine regimens formulated with combinations of different adjuvants, including one from the Army Liposome Formulation (ALF) fam...
Gary Matyas Josphat Kosgei Walter Reed Army Institute Of Research National Institute Of Allergy Research Programs Research Program

The Week That Will Be

The Week That Will Be Event Announcements (More details on the Events Calendar) Tuesday, March 16, 2021, at 9:30 a.m.: The Senate Armed Services Committee will hold a hearing on U.S. Southern and Northern Commands. The committee will hear testimony from Adm. Craig Faller, commander of Southern Command, and Gen. Glen VanHerck, commander of Northern Command.  Tuesday, March 16, 2021, at 11:00 a.m.: The House Armed Services Subcommittee on Intelligence and Special Operations will hold a hearing o...
United States Hong Kong White House District Of Columbia Fletcher School City Of

BioXcel Therapeutics Reports Fourth Quarter and Full Year 2020 Financial Results and Provides Business Update

Published: Mar 11, 2021 New Drug Application (“NDA”) submitted to the U.S. Food and Drug Administration (“FDA”) for BXCL501 for the acute treatment of schizophrenia and bipolar disorder related agitation TRANQUILITY achieved primary and secondary endpoints with both doses of BXCL501; End of Phase 2 meeting with the FDA planned for Q2 2021 RELEASE trial on track to report topline results in Q1 2021 Topline results from two ongoing trials with BXCL701 in aggressive forms of prostate...
United States Yale University John Graziano Julia Deutsch Javier Rodriguez Mary Coleman

BioXcel Therapeutics Reports Fourth Quarter and Full Year 2020 Financial Results and Provides ...

Press release content from Globe Newswire. The AP news staff was not involved in its creation. BioXcel Therapeutics Reports Fourth Quarter and Full Year 2020 Financial Results and Provides ... BioXcel TherapeuticsMarch 11, 2021 GMT New Drug Application (“NDA”) submitted to the U.S. Food and Drug Administration (“FDA”) for BXCL501 for the acute treatment of schizophrenia and bipolar disorder related agitation TRANQUILITY achieved primary and secondary endpoints with both doses of BXCL50...
United States Yale University John Graziano Julia Deutsch Javier Rodriguez Mary Coleman
Source: apnews.com

Research offers insights on how night shift work increases cancer risk

 E-Mail IMAGE: A night shift schedule is associated with increased DNA damage and misalignment of the DNA repair mechanism, providing a possible explanation for the elevated risk of cancer in night shift... view more  Credit: Bala Koritala SPOKANE, Wash. - New clues as to why night shift workers are at increased risk of developing certain types of cancer are presented in a new study conducted at Washington State University Health Sciences Spokane. Journal of Pineal Research, the stud...
Hugh Mitchell Van Dongen Jason Mcdermott Kenneth Porter Justin Teeguarden Hans Van Dongen

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RICE UNIVERSITY: Cancer 'guardian' breaks bad with one switch – India Education,Education News India,Education News

Study shows how mutant protein clusters drive disease-causing aggregates A mutation that replaces a single amino acid in a potent tumor-suppressing protein turns it from saint to sinister. A new study by a coalition of Texas institutions shows why that is more damaging than previously known. The ubiquitous p53 protein in its natural state, sometimes called “the guardian of the genome,” is a front-line protector against cancer. But the mutant form appears in 50% or more of human cancers and ...
University Of Houston United States Rice University University Of Texas David Yang Navin Varadarajan

BCAS3-C16orf70 complex is a new actor on the mammalian autophagic machinery

 E-Mail IMAGE: The confocal microscopy image of cell induced mitophagy. Autophagic membranes engulf the damaged mitochondria. TOMM20 (blue) is mitochondrial outer membrane protein and WIPI2 (red) is well-known autophagy protein. BCAS3-C16orf70 (green)... view more  Credit: TMIMS Autophagy is an intracellular degradation process of cytosolic materials and damaged organelles. Researchers at Ubiquitin Project of TMIMS have been studying the molecular mechanism of mitophagy, the selective a...
Life Science Research Tokushima University Institute Of Advanced Medical Sciences Research Programs University Of Tokushima Takeda Science Foundation

Cancer 'guardian' breaks bad with one switch

 E-Mail IMAGE: A model produced by scientists at Rice University shows the conformational changes caused by a mutation in the cancer-fighting p53 protein. At top left, the red box highlights the aggregation-prone... view more  Credit: Kolomeisky Research Group/Rice University HOUSTON - (March 4, 2021) - A mutation that replaces a single amino acid in a potent tumor-suppressing protein turns it from saint to sinister. A new study by a coalition of Texas institutions shows why that is m...
University Of Houston United States Rice University University Of Texas David Yang Navin Varadarajan

Press Release: 2021 Peer Reviewed Cancer Research Program, Congressionally Directed Medical Research Program

Anticipated Funding Opportunities for Fiscal Year 2021 (FY21) The FY21 Defense Appropriations Act provides funding to the Department of Defense Peer Reviewed Cancer Research Program (PRCRP) to support innovative, high-impact cancer research. As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency J9, Research and Development Directorate manages the Defense Health Program (DHP) Research, Development, Test, ...
United States Program Announcements National Cancer Institute Behavioral Health Science Award Us Department Of Veterans Affairs Defense Health Program
Source: army.mil

These Five Genes Play Role in Lewy Body Dementia, Parkinson's - Physical Therapy Products

A study led by the National Institutes of Health researchers appears to have located five genes that may play a role in whether a person will experience Lewy body dementia. Lewy bodies are also hallmarks of Parkinson’s and Alzheimer’s diseases. “Lewy body dementia is a devastating brain disorder for which we have no effective treatments. Patients often appear to suffer the worst of both Alzheimer’s and Parkinson’s diseases. Our results support the idea that this may be because Lewy bo...
United States Bryanj Traynor Clifton Dalgard Sonja Scholz American Genome Center National Institutes Of Health

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